Ukraine launched a significant drone and missile attack on Russian regions overnight, causing damage to at least two factories and leading to the closure of schools in a large southern Russian city, according to Russian officials and media reports.

The Shot Telegram channel mentioned that Russia successfully shot down over 200 Ukrainian drones and five US-made ATACMS ballistic missiles. "The enemy has organised a massive combined strike on the territory of the Russian regions," the Two Majors war blogger said. The governor of western Russia's Bryansk district, Alexander Bogomaz, claimed that Ukraine had launched a significant missile attack, but he did not specify which missiles were deployed. Russia's defence ministry, which covers these kinds of attacks, did not immediately respond. The reports were not immediately verified by Reuters. 

In the Russian city of Engels, where Russia's nuclear bombers are based, Saratov Governor Roman Busargin reported that a drone had damaged an industrial facility, but he did not provide further details. Busargin also announced that schools in Saratov and Engels would conduct classes remotely. Additionally, flight restrictions were imposed in the cities of Kazan, Saratov, Penza, Ulyanovsk, and Nizhnekamsk, according to Russia's aviation authority. The large Taneco refinery is located near Nizhnekamsk, in the Tatarstan region of Russia. Attack sirens were activated at the refinery, according to Shot. The report could not be immediately verified by Reuters. 

On November 21, Russia launched a new intermediate-range hypersonic ballistic missile called "Oreshnik" (or Hazel Tree) at Ukraine. President Vladimir Putin said this was a direct response to Ukrainian forces' attacks on Russia using US and British missiles. After these attacks, Putin stated that the war in Ukraine was escalating into a global conflict. He also warned the West, saying that Moscow could retaliate for allowing Ukraine to strike Russia with their weapons. Washington's long-term support for Ukraine is in doubt as President-elect Donald Trump has pressed for a ceasefire and talks to settle the conflict swiftly.  In 2022, Russia invaded Ukraine, killing tens of thousands, uprooting millions, and igniting the most severe crisis in Moscow-West relations since the Cuban Missile Crisis in 1962.